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In this study, we examined the analgesic effect of nicotine in two rat neuropathic pain models

Groups 12: This group was received IP co-administration of subanalgesic doses of vitamin B 12 (25 g kg -1 ) plus diclofenac (0.25 mg kg -1 ) for 10 consecutive days after surgically-induced crush injury in tibial nerve

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FIGURE 1 FIGURE 2 Individual-centric spheroids did not show cell over proliferation in long-term cell culture conditions The use of immortalized cell lines such as HepG2 or Huh7 to generate spheroids for DILI assessment often suffers from excessive uncontrolled cell proliferation resulting in enlarged spheroids with a necrotic core that can alter drug penetration and drug responses and thereby reducing the physiological relevance and predictive accuracy of the model

Sex-Specific Differences in Lipid and Glucose Metabolism