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In both humans and rodents, alcohol is a potent anxiolytic, which could explain why individuals suffering from mood and anxiety disorders use alcohol to cope with the difficult symptoms associated with these disorders 6

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Although over 2000 different mutations in the p53 gene have been reported in human cancers [84], most mutations occur at six hotspot amino acid residues in the DNA-binding domain (R175, G245, R248, R249, R273 and R282) [85]

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