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It was discovered that Sdd3 negatively regulates the upstream activating factor Rho1 GTPase through direct interaction with the GTPase-activating protein Bem2 of Rho1, thereby significantly reducing the chitin content in the fungal cell wall and causing defects in biofilm formation

10.1111/j.1749-6632.1981.tb30907.x [DOI] [PubMed] [Google Scholar] 31.Lewis RF
Namorado et al

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease