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Lack of Creatine production results in prolonged lack of energy, with prolonged over-usage or underproduction eventually leading to the subject being chronically fatigued (CFS) Reduced production of Creatine has been associated with many conditions including dementia, Parkinson's disease, Autism, Chronic Fatigue Syndrome

The changes in SOD activity in a particular compartment may lead to the generation of a hydrogen peroxide concentration gradient and the subsequent activation of redox sensitive pathways