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Consistent with this, a synthetic PAI-1 inhibitor can prevent trabecular bone loss by stimulating bone formation and also suppressing osteoclastogenesis in OVX mice (237)

Boyle, A

Additionally, premature ovarian failure or androgen deprivation (from cancer therapies) can produce hormonal changes associated with fatigue for example, abrupt menopause in women or testosterone deficiency in men may precipitate lethargy and muscle weakness

Paired-end reads were assembled by using PEAR v0.9.8 [32]