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To produce lentiviral particles, 1 10 7 HEK293T cells in a 55-cm 2 dish were co-transfected with 10 g pLKO.1 shRNA construct, 5 g psPAX2, and 5 g pMD2G

The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S

Lanznaster, D