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Unlike platinum-induced mitochondrial dysfunction, vincristine may alter mitochondrial Ca 2+ signal transduction [5, 6] and promote signal expression in the process of inducing oxidative damage (including NOX1, NOX2 and iNOS), leading to oxidative stress of sciatic nerve tissue, and antioxidants such as HO-1 and NQO-1 are highly decreased [28]

This can supplement diet, exercise, and other nonpharmacologic interventions

Apart from the introduction of bacteria, you are also causing irritation to the skin which can increase the risk of acne scars

Source PMC

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