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However, cases of brain damage caused by PQ began to be reported (Grant et al., 1980
In contrast to SOD2, SOD1 is comparatively resistant to cyanide
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While it is not fully known why primary and secondary non-response occurs in CD, one hypothesis is that free anti-TNF concentrations become inadequate due to increased drug clearance from multiple causes including the presence of antibodies to infliximab or adalimumab, and that some patients disease may be mediated through non-TNF pathways
