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It has a higher molecular weight (4,813 versus 4,114 Daltons)

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Population estimate of people with clinical AD and mild cognitive impairment in the United States (20202060)

The p K a of the histidine imidazole group is 6.5, and thus histidine behaves as hydrophobic residue at neutral pH, whereas it is protonated and behaves as a basic peptide in the slightly acidic endosomal milieu
