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Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

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The tirzepatide participants who received the drug once a week shed 15-20 percent of their body weight on average over 72 weeks, compared to the placebo group