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Interleukin 1beta and tumour necrosis factor alpha secreting cells are increased in the peripheral blood of patients with primary Sjgren's syndrome

(A) Fresh NAC standard, (B) NAC standard at RT for 24 h, (C) NAC standard at RT for 48 h, (D) NAC standard at 37 C for 24 h, (E) NAC standard at 37 C for 48 h, (F) Placebo sample at RT for 24 h, (G) Placebo sample at RT for 48 h, (H) Placebo sample at 37 C for 24 h and (I) Placebo sample at 37 C for 48 h

GSTP1 conjugates and detoxifies ethacrynic acid (Ahokas et al, 1984), which was significantly more toxic to GSTP1 null cells (1.3-fold increase in IC 50 , P =0.004, Figure 2A)

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