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JCI Insight 2 , e90019 (2017)

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

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For oral B12 supplementation with a supplement like Cobalequin, 250 micrograms must be given once daily and continued initially for 12 weeks