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However, cross-reactivity with INSR-B can modulate glucose metabolism in vivo, leading to insulin resistance and hyperglycemia [21, 71, 72]

10.1002/pros.23013 167
By inhibiting GPX4 and GSS, solasonine increased the amounts of lipid ROS in HepG2 cells to produce these effects (132)

In: Principles and Methods of Toxicology

The cells were filtrated through a 70-m cell strainer and washed with cold PBS buffer to remove cell clumps and debris