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Elevated plasma concentrations of IS and pCS may arise through two distinct mechanisms: impaired clearance secondary to compromised glomerular filtration, or pathological triggering events during early disease phases (155)

Hereditary difference in the expression of the human glutathione S-transferase active on trans-stilbene oxide are due to a gene deletion

Any alteration in the tight junction structure can prove to be detrimental to the organism

Kidney Dysfunction: In chronic kidney disease (CKD) or renal failure, the bodys ability to filter and excrete B12 may be compromised, leading to accumulation in the blood 8

The evolving cardiac lymphatic vasculature in development, repair and regeneration