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Description
There is no HPTA suppression, no receptor downregulation comparable to what you would observe with a hormone or secretagogue

What Clinical Studies Have Found Several clinical studies have researched the connection between using Ozempic and vitamin B12 levels, discovering that the rate of vitamin absorption lowers when taking semaglutide

This affects all SAM-dependent reactions, for example the nerves through reduced production of myelin and acetylcholine but also neurotransmitter synthesis and degradation in the biopterin cycle, as we discussed above

[DOI] [PubMed] [Google Scholar] Caronti B, Tanda G, Colosimo C, Ruggieri S, Calderaro C, Palladini G, Pontieri FE, Di Chiara G (1999) Reduced dopamine in peripheral blood lymphocytes in Parkinsons disease

The mechanism behind this is still unclear, although mutations in ubiquitin-specific protease 8 ( USP8 ), a deubiquitinase enzyme with various targets including EGFR, leading to hyperactivation of this enzyme and subsequent increased EGFR deubiquitination and recirculation to the cell surface, enhance the release of ACTH (147,150)
