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Zinc is crucial to the structure and function of Cu/Zn-SOD, accounting for about 90% of total SOD, which exerts protective effects on tissues from oxidative damage (159)

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A phase Ib/II clinical trial (NCT03072043) revealed abundant effects when APR-246 was combined with azacitidine (AZA) in MDS patients and AML patients carrying mutant p53

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Smith GA, Gross SP, Enquist LW
