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We also compared organoid metabolism to human liver microsomes and the human S9 fraction (unfractionated microsomes and cytosol)

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model

doi: 10.1016/j.redox.2014.01.002

Kassis ES, Vaporciyan AA, Swisher SG , Correa AM, Bekele BN, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Moran CA, Pisters KM, Rice DC, Walsh GL, Roth JA

While PEGylation enhances circulation time and reduces immune recognition of nanoparticles, excessive PEGylation might hinder the efficient interaction of LNPs with target cells, leading to reduced therapeutic effects (Kumar et al., 2014), and fusion of the LNPs with the endosomal membrane due to steric hindrance, leading to therapeutic inefficacy (Aldosari et al., 2021