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MicroRNA-183-5p increases with age in bone-derived extracellular vesicles, suppresses bone marrow stromal (stem) cell proliferation, and induces stem cell senescence

However: Results are not standardized False positives and false negatives can occur Testing carries a risk of severe allergic reaction , including anaphylaxis For these reasons, it should only be performed by experienced allergy specialists and is not required for diagnosis

**NRV not established

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The process of freezing and thawing can create ice crystals that damage the delicate protein structures, leading to a significant loss of potency