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Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency

Upregulation of TXNIP by ROS stimulated the NLRP3 inflammasome, which activated the protease caspase-1 to facilitate the release of inflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 (IL-1) and triggered inflammatory responses

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The paper from first to final draft was written and edited by RHC with the help of his co-authors who offered suggestions for improvement

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