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The trx-2 and trxr-2 genes comprise the mitochondrial thioredoxin system and are upregulated upon induction of the mitochondrial unfolded protein response (UPR mt ) [152,153]

Abstract Despite the worldwide acceptance of acetaminophen (APAP) as a necessary medicine in pediatrics, evidence that early exposure to APAP causes neurodevelopmental injury in susceptible babies and children has been mounting for over a decade

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