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Pesca and coauthors, [244] demonstrated the antiangiogenic activity of five proanthocyanindins, including the new natural compounds (2S)-4,5,7-trihydroxyflavan-(4 8)-epiafzelechin, (2S)- 4,5,7 trihydroxyflavan -(4 8)-afzelechin, proanthocyanidin A2, geranin B, and proanthocyanidin

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These agents can be classified into several categories based on their mechanisms of action and chemical structures, including inhibitors of sterol synthesis, cell wall synthesis, DNA synthesis, and cell membrane function