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Further in vitro research supported their findings by showing that the increased oxidative stress induced by METH is reversed upon the treatment of SH-SY5Y neuronal cells with selenium, possibly through a reduction in glutathione peroxidase (GPx) levels

For significant associations, we tested the potential explanatory effect of lifestyle and health-related variables by further including alcohol consumption, smoking status, physical activity, BMI and the number of self-reported current somatic diseases in the analytical models

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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11,86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression