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(2003) Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study

Direct to Phase II: Department of Defense may issue a Phase II SBIR award to an SBC that did not receive a Phase I SBIR or STTR award for that R/R&D

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Oral / capsule formulations more convenient, especially for gut-health applications, but may be less efficient for musculoskeletal repair

This activates the nitrile carbon towards nucleophilic attack, which occurs with water (Step 2, arrows C and D)