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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

This makes it a valuable tool for individuals suffering from conditions such as Crohns disease, ulcerative colitis, and irritable bowel syndrome (IBS) (Sikiric et al., 2016)

BPC-157 increases serotonin synthesis in certain brain regions and counteracts serotonin excess in others, making the net effect when combined with serotonin reuptake inhibitors unpredictable and potentially dangerous
