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Compared to partial sciatic nerve ligation (pSNL), the CCI model demonstrates more pronounced effects in inducing mechanical allodynia, thermal hyperalgesia, and cold allodynia (4, 49, 50), and reliably elicits spontaneous pain-like behaviors (51, 52), along with fewer ectopic pain-like behaviors (53), typically within 1014 days post-surgery

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alpha-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility