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High performance liquid chromatography For measurements of HCY, cysteine (CYS), GSH, SAM and S-adenosyl-L-homocysteine (SAH), cell precipitates from aliquots A and B were diluted in Milli-q H 2 O 1:2 and the cells disrupted by three freeze/thaw cycles (20 to -20C)

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In a 56-day phase-2 trial, 9 participants with severe dry eye syndrome were treated with synthetic TB4 eye drops or placebo for 28 days, followed by a 28-day observational period