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For example, senescent astrocytes show upregulated expression of IL-6, IL-8, IL-1, MMP3, MMP10, and TIMP2, while neuroprotective factors such as IL-10, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) are downregulated (Lye et al., 2019)

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The novel point was the rapid activation of the collateral rescuing pathways (i.e., activation of the azygos veins direct blood flow delivery) to reestablish the reorganized blood flow [4,10]

How is the free Cu fraction structurally defined and where exactly is it generated