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The combination of phenylbutyrate (PBA) and 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D3) induces LL-37 expression in a lung epithelial cell line and enhances M.tb killing in human monocyte-derived macrophages through activation of autophagy and resolution of lung pathology [150]

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Covarrubias, A

Jul 4 2016;116(1):162-71

It has anti-inflammatory properties, which means it lowers pro-inflammatory mediator levels

This unique conjugated structure profoundly alters the half-life, metabolism and clearance, as well as the biodistribution and composition of each component [95]
