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Two other studies demonstrated that the silica exposure-induced overproduction of ROS is associated with the degradation of the NF-B inhibitor IB- and activation of the NF-B pathway because a pretreatment with NAC decreased a silica-induced accumulation of ROS and inhibited the suppression of IB- [179], or reduced the activation of NF-B [187]

Chin J Cancer Res

V., DeSilva T

The primary outcome was compared between the two treatments using a paired Wilcoxon signed-rank test (performed on the intra-patient differences)

5.3 Distinct mechanisms of adipocyte elimination in metabolic disease AT undergoes several forms of cellular elimination under metabolic stress: mitochondrial-dependent apoptotic pathways, inflammatory cell death via receptor-interacting serine/threonine-protein kinase 3 (RIPK3)/Mixed lineage kinase domain-like protein (MLKL) signaling, and inflammasome-triggered membrane disruption through specific molecular cascades (392)