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DHT treatment in mouse osteoblasts increased Akt activity within 15-min and induced AR-dependent maximal nuclear translocation of Akt kinase within 40-min of treatment [122]

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In agreement with in vitro findings, fewer proliferating and more apoptotic cells were observed in xenograft tumors with CRAT overexpression, as evidenced by Ki-67 and TUNEL staining assays (Fig

In particular, changes in the expression/function of OCTN2 and CT2 have been observed in human cancers indicating that cell supply of carnitine is strictly regulated during cancer development and that chemical KO of these proteins may serve as a strategy to impair energy production from FAO