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Trummer M, Flaschka G, Unger F, et al

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Epithalon injected to rats exposed to any photoregimen also significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias

These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it