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During bone resorption by osteoclasts, multiple growth factors and cytokines are acvitated and released from the bone matrix to recruit MSCs and induce differentiation into mature osteoblasts in coupling bone formation with resorption (5,20,29,31,32)

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[DOI] [PubMed] [Google Scholar] 52.Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.I

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It has increasingly become evident that EVs, including exosomes could participate at several stages of tumor progression, from initiation, invasion to metastasis