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People with Lebers hereditary optic neuropathy, a rare inherited optic nerve disorder, may be at risk of severe optic nerve damage with cyanocobalamin

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For maintenance or prophylactic use (such as in a patient with short-gut syndrome who cannot absorb oral vitamins well), a common regimen is 1 mL IM once weekly

The memory-like g - NK cells are activated after CD16 crosslinking

In addition, obtaining certain therapeutic radionuclides like Actinium-225 and Astatine-211 is difficult due to the limited number of facilities producing these radionuclides
