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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

Fragment 176-191 Safety Studies There is some concern that the use of hGH or its derivatives for weight control may have unwanted side effects

Supplement, it really comes down to individual needs, lifestyle, and health conditions

There are no FDA-approved HCG products for weight loss, and the FDA requires prescription HCG labeling to state it has not been shown to increase weight loss, improve fat distribution, or reduce hunger

However, it is important to note that the fragment appears to lack any other associated action of hGH, such as a potential increase of IGF-1 (insulin-like growth factor-1), insulin resistance, or cell proliferation