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Similar content being viewed by others Introduction Acute ischemia/reperfusion (I/R) refers to a temporary abolishment of blood flow during surgical interventions, followed by its re-establishment once an intervention is finished 1

Methods Selected scientific articles in MEDLINE/PubMed, Scopus, The Cochrane Library, British Library EThOS and TESEO databases were assessed for this systematic review

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The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment