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ROS generated by NE metabolism cause intracellular Ca 2+ overload either by modulating calciumhandling proteins or inducing membrane lipid peroxidation (143)
Based on this multifaceted activity, the authors proposed GHK-Cu as a promising therapeutic candidate to help prevent or slow age-associated neurodegenerative disorders and cognitive decline, positioning it as a potential epigenetic and regenerative agent rather than a single-target drug
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Nat Commun (2013) 4:1366
(8890), and is associated with tumor progression, invasion, and metastasis (91)
