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HEP-1 also activated the PI3K-AKT signaling pathway, increased the expression of endothelial nitric oxide synthase (eNOS), promoted the expression of serum and glucocorticoid-induced kinase (SGK), and enhanced the biosynthesis of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), thereby facilitating the repair and healing of gastric mucosal injury (GMI)

The world average Hg concentrations reported in coal and FA are 0.011 and 0.62 mg/kg, respectively

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