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Betaine synergistically enhances obesity and its metabolic complications through various targets via the AMPK-mitochondrial axis, SIRT1/SREBP-1/PPAR signaling, inhibition of inflammation, and the microbiota-SCFA-epigenetic cascade, providing a mechanistic basis for its clinical translation

The main hormones that activate the HPA axis are corticotropin-releasing factor (CRF), arginine vasopressin (AVP) and adrenocorticotropin hormone (ACTH)

This intramuscular injection is specifically indicated for the treatment of deficiencies of these essential vitamins

Antioxidants 9 , 74 (2020)