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Discussion We have reviewed a growing body of preclinical and clinical studies conducted over the past two decades that have examined the development and efficacy of IN CNS therapeutics

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The formulations uniqueness lies in delivering synergistic quantities of methyl-donor amino acids (methionine and choline), a carnitine shuttle cofactor, and a provitamin B derivative in one injection, thereby bypassing gastrointestinal absorption limits that may hinder oral supplementation