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The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

Senescence and the SASP: many therapeutic avenues

Although the age-adjusted mortality rate for cardiovascular disease has diminished in industrialized countries owing to life-style changes, smoking cessation, advances in biomedical research, and improvements in medical care and technologies, the aging population and burgeoning epidemic of cardiometabolic disease characterized by obesity, insulin resistance, dyslipidemia, impaired glucose tolerance, and hypertension, threatens to reverse this progress, underscoring the requirement for additional therapeutic options that target this deadly disease

Doctors often recommend this treatment for conditions such as herniated discs, spinal stenosis, sciatica, or chronic low back pain

also potentially leading to an even-toned and radiant complexion