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25 The activated IGF-1 receptor is capable of phosphorylating other tyrosine containing substrates, such as insulin receptor substrate 1 (IRS-1), and continues a cascade of enzyme activations via phosphatidylinositol-3 kinase (PI3-kinase), Grb2 (growth factor receptor bound protein 2), Syp (a phophotyrosine phosphatase), Nck (an oncogenic protein), and Shc (src homology domain protein), which associated to Grb2, activates Raf, leading to a cascade of protein kinases including Raf, mitogen activated protein (MAP) kinase, 5 G kinase, and others

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Miyazawa, The oxidation of 8-oxo-7,8-dihydroguanine by iodine

To view a copy of this licence, visit About this article Cite this article Snelson, M., Vanuytsel, T

As to patient-sets, the fatigued and non-fatigued group at S-HD (M0) was defined as Fatigue-S (FS), and at E-HD (M12) as Fatigue-E (FE), and comparisons of all patients between at S-HD (M0) and E-HD (M12) as EHD