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Loading phase (deficiency): 1000 mcg IM or subQ daily or every other day for 1 to 2 weeks Maintenance: 1000 mcg monthly is a standard maintenance dose for conditions like pernicious anemia Wellness protocols: may use lower doses weekly, though this is less established clinically In ml: cyanocobalamin is typically supplied at 1000 mcg/ml, so a 1000 mcg dose equals 1 ml

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The catalytic triad of MGL is formed by Ser-122, Asp-239, and His-269

A two-year analysis of Modernas mRNA-1273, covering over 772 million doses, reported that 0.7% of the more than 2.5 million AEs led to fatalities (~17,500 deaths total)