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Obesity and diabetes are associated with non-alcoholic steatohepatitis

This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

POPs disrupt cardiovascular homeostasis by interfering with estrogen signaling, impairing blood pressure regulation, and inducing oxidative stress-mediated inflammation [52]

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NASH often progresses silently and may be related to dietary imbalances , sedentary lifestyle, overweight, or certain predispositions