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The patients who respond to thiamin treatment (from a few mg/day to doses above 1,000 mg/day) exhibit PDHC deficiency due to the decreased affinity of PDHC for TPP (108, 109)
Reconstitution: Add 2.0 mL bacteriostatic water 5 mg/mL total peptide concentration (5000 mcg/mL combined)
10.1073/pnas.141230798PubMed Abstract | CrossRef Full Text | Google Scholar 125 SalinasA
These medications should be avoided by people who are pregnant or breastfeeding, those with a history of pancreatitis, and anyone with a personal or family history of medullary thyroid cancer or MEN2 syndrome
