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Even Avecho Biotechnology (formerly Phosphagenics), a company who wanted to repurposed AOD-9604 as a transdermal formulation, knew why the clinical trials failed: AOD9604s delivery could have been the key issue
doi: 10.1016/j.exer.2006.08.004
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Match it to the sequence rather than defaulting to water for everything

The high dose of cyanocobalamin is generally well-tolerated due to the vitamins water-soluble nature and efficient excretion of excess amounts
