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[89] found that EGF markedly increases TRPM6 activity, and a baseline activity of basolateral EGFR activation is required for TRPM6 activity and apical Mg2+ entry
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That triple mechanism is what produced the headline-grabbing results from the Phase 2 NEJM trial, where the 12 mg dose group achieved an average 24.2% body weight reduction over 48 weeks
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PMID 6897451.
