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Two primary reasons: First, immunogenicity

The ability of the BBB to absorb Se-NPs, which maintain a healthy microenvironment, is essential for the homeostasis of the brain

[DOI] [PubMed] [Google Scholar] 68.Madi V., Petrovi A., Jukovi M., Jugovi D., Djordjevi L., Stojanovi G., Vasiljevi P

Direct gene therapy to the fetus sounds promising, even though it would raise other ethical and safety concerns which are beyond the scope of this review (Shangaris, 2020)

PI-DTP cells from MM patients display significant enrichment of HDAC genes
