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By modulating astrocytic activity through targeted regulation of relevant signaling pathways, it may be possible to improve cognitive function and safeguard against neurodegenerative diseases (Verkhratsky and Nedergaard, 2018)

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The structural similarity between IGF1R and the insulin receptor means LR3 can be used to probe questions about cross-receptor signaling and the metabolic effects of IGF axis activation

Int J Drug Discov Pharmacol

High circulating IGF-1 levels have been positively correlated with bad prognosis in patients undergoing endocrine therapy [28], while another study found that high serum IGF-1 is associated with increased all-cause mortality in a cohort of women with established breast malignancy [29]