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Various models are used to study PD, including -synuclein-mutant mice, the toxin MPTP, striatal injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA), and others (115)

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However, discontinuation rates are similar for both treatments (approximately 6%), suggesting that while CagriSema causes more frequent gastrointestinal symptoms, they are generally manageable