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For instance, one study notes that people with excess weight or obesity appear to have lower vitamin B12 levels than people who have a body mass index (BMI) in the normal range ( Additional research has observed that people who voluntarily took vitamin B12 supplements gained between 2.517 fewer pounds (1.27.7 kg) over 10 years than those who did not supplement with this vitamin ( Still, such observational studies cannot confirm whether low vitamin B12 levels are what caused the weight gain, nor whether theyre what protected against low levels

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Biological sex is a primary variable, not a secondary one

Subcutaneous administration achieves similar bioavailability while avoiding deeper tissue penetration

Doctors say most patients do well on methotrexate alone, a drug thats been used for RA since the 1980s, and want to avoid the added expense and toxicity of unnecessary medications